The main campus of the South Carolina School for the Deaf and the Blind (SCSDB) is located in the Upstate of South Carolina and its five Regional Outreach Centers are located throughout the state. SCSDB offers programs for preschool, elementary, middle school, high school, sensory multidisabled, and vocational students in addition to a vast array of outreach services.

SCSDB was founded in 1849 by Rev. Newton Pinckney Walker and his wife Martha Hughston Walker when they opened their home as a private school, admitting five children who were deaf. The school became a state school in 1856.

The South Carolina State Department of Education (SDE) has named the school a Palmetto Gold School for academic accomplishments and a Red Carpet School for outstanding customer service and a family–friendly environment. It is accredited by the Southern Association of Colleges and Schools/Council on Accreditation and School Improvement (SACS/CASI), the Conference of Educational Administrators of Schools and Programs for the Deaf (CEASD) and SDE.